Automatic PFS Filling and Closing Machine for PP Prefilled Syringe Manufacturing
DROFEN MACHINERY develops automatic PFS filling and closing machines for PP prefilled syringe production projects. The equipment is designed to support stable filling performance, coordinated product transfer, and reliable process control in automated pharmaceutical manufacturing.
According to production capacity and product requirements, the machine can be configured with 6-head or 8-head filling layouts. It is suitable for projects requiring efficient filling and closing of polypropylene syringes, while also allowing integration with selected downstream modules such as visual inspection, plunger rod insertion, labeling, and packaging.
Rather than functioning as a generic filling unit, this machine is developed as a dedicated PP syringe filling and closing platform that can be adapted to different project stages, from new line planning to capacity expansion for larger-volume manufacturing.
Key Features of Our Filling and Closing Line
Configurable Filling Capacity: The machine is available in 6-head and 8-head configurations. The 6-head version supports stable output up to 230 syringes per minute, while the 8-head version supports stable output up to 300 syringes per minute, depending on product format and process conditions.
Designed for PP Syringe Projects: Developed specifically for polypropylene prefilled syringe production, the machine is configured to support the handling and filling characteristics of PP syringe components.
Coordinated Filling and Closing Process: The equipment integrates key process steps required for automated filling and closing, helping improve production stability and consistency in continuous manufacturing.
Downstream Integration Capability: According to project scope, the machine can be connected with inspection, plunger rod insertion, labeling, or packaging modules to support broader production workflows.
Suitable for Aseptic Manufacturing Environments：The system can be configured according to aseptic production requirements and clean manufacturing project standards.
Typical Production Workflow for PP Prefilled Syringe Filling and Closing
The machine is designed for a coordinated production sequence covering key filling and closing steps for PP prefilled syringes. Syringe components are fed into the system in a controlled manner, followed by product transfer, liquid filling, and closing-related operations according to the required process configuration.
For projects requiring broader automation scope, the machine can also be connected with downstream inspection, plunger rod insertion, labeling, or packaging stations. This allows customers to build a more complete production workflow while keeping the filling and closing machine as the core processing unit.
Component Feeding:
Pre-sterilized PP barrels, plunger stoppers, tip caps, and rods are loaded via vibratory bowls for synchronized, scratch-free delivery.
Simultaneous Assembly and High-Speed Filling:
Engineered specifically for plastic components, the machine simultaneously assembles the syringe quartet without friction damage. Using 6 or 8 high-precision filling heads, it injects the solution under positive pressure, sealing with the tip cap and stopper under vacuum to prevent air entrapment.
Quality Checkpoint:
Syringes advance to the inspection unit, where high-intensity LED lighting and cameras scrutinize every plastic unit for absolute compliance.
Labeling and Insertion:
An inline station inserts the plunger rod with precise torque control and applies secure, scannable labels, ensuring full traceability.
Final Sealing:
The pillow packaging unit wraps completed syringes in protective film, automating the entire process from start to sterile finish..
Why Choose DROFEN for PFS Filling and Closing Projects?
DROFEN focuses on automated pharmaceutical equipment development for projects that require stable production performance and practical manufacturing integration. For PP prefilled syringe applications, we provide equipment configuration support based on production target, project scale, and downstream connection requirements.
Our goal is not only to supply equipment, but also to help customers define a more suitable filling and closing configuration for their actual manufacturing needs. Whether the project is for a new production line or for capacity expansion, we support customers with clearer technical communication and equipment matching.
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